Jaspamycin (Synonyms: 7-CN-7-C-Ino) |
| カタログ番号GC65303 |
ジャスパマイシン (7-CN-7-C-Ino) は PKA の強力な活性化因子であり、R 部位 (PKAR) に結合し、Trypanosoma brucei で 6.5 nM の EC50 と 8 nM の Kd を持ちます。
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Cas No.: 22242-96-2
Sample solution is provided at 25 µL, 10mM.
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Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity[1].
[1]. Sabine Bachmaier, et al. Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun. 2019 Mar 29;10(1):1421.
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