Jatrorrhizine (chloride) (Synonyms: NSC 645313) |
| カタログ番号GC43926 |
Jatrorrhizine (塩化物) は、Coptis chinensis から分離されたアルカロイドで、神経保護、抗菌、抗原虫、抗酸化作用があります。
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Cas No.: 6681-15-8
Sample solution is provided at 25 µL, 10mM.
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Jatrorrhizine is an alkaloid that has been found in the Chinese herb C. chinensis and has diverse biological activities. It is active against P. falciparum (IC50s = 422 and 1,607 ng/ml for D-6 and W-2 clones, respectively) and E. histolytica (IC50 = 82.7 μM). Jatrorrhizine inhibits the growth of C8161 human melanoma cells in vitro (IC50 = 47.4 μM) and inhibits C8161 cell-mediated neovascularization in a Matrigel™ plug assay in mice when administered at a dose of 50 μg/animal. It reduces serum levels of triglycerides, LDL cholesterol (LDL-C), aspartate transaminase (AST), and alanine aminotransferase (ALT) in a high-fat diet-induced mouse model of hyperlipidemia when administered at doses of 20 and 100 mg/kg. Jatrorrhizine is also a metabolite of berberine .
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