K-41 |
| カタログ番号GC47523 |
抗生物質および寄生虫活性を持つ真菌代謝産物
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 53026-37-2
Sample solution is provided at 25 µL, 10mM.
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K-41 is a monoglycoside polyether fungal metabolite originally isolated from S. hygroscopicus that has antibiotic and antiparasitic activities.1,2 It is active against B. subtilis, B. anthracis, S. aureus, S. pyogenes, S. pneumoniae, C. diphtheriae, and M. tuberculosis (MICs = 3.13, 1.56, 1.56, 0.78, 0.39, 0.78, and 3.13 µg/ml, respectively).1 K-41 is active against the K1 drug-resistant and FCR3 drug-susceptible P. falciparum strains (IC50s = 8.5 and 31 nM, respectively).2 In vivo, K-41 has antiparasitic activity in mouse models of P. berghei and P. yoelii infection (ED50s = 1.9 and 7.0 mg/kg, respectively).
1.Tsuji, N., Nagashima, K., Kobayashi, M., et al.Two new antibiotics, A-218 and K-41. Isolation and characterizationJ. Antibiot. (Tokyo)29(1)10-14(1976) 2.Moreno, M., and Giralt, E.Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: Melittin, apamin and mastoparanToxins71126-1150(2015)
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