Kauran-16,17-diol (Synonyms: ent-Kauran-16β,17-diol) |
| カタログ番号GC60962 |
天然のジテルペンであるカウラン-16,17-ジオール (ent-カウラン-16β,17-ジオール) は、抗腫瘍活性およびアポトーシス誘導活性を有し、LPS 刺激 RAW 264.7 マクロファージにおける NO 産生の阻害に対する IC50 は 17 μM です。 。
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Cas No.: 16836-31-0
Sample solution is provided at 25 µL, 10mM.
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Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2].
Kauran-16,17-diol (ent-Kauran-16β,17-diol) down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells[1].
[1]. Alvaro Morales, et al. The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. Apoptosis. 2011 Dec;16(12):1245-52. [2]. Nguyen Xuan Nhiem, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett. 2015 Jan 15;25(2):254-8.
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