Kynuramine dihydrochloride |
| カタログ番号GC63035 |
内因性アミンであるキヌラミンは、血漿アミンオキシダーゼの蛍光基質およびプローブです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 36681-58-0
Sample solution is provided at 25 µL, 10mM.
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Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2].
Kynuramine inhibits both presynaptic and postsynaptic α-adrenoceptors in vitro[2].Kynuramine has been shown to act as a partial agonist on serotonin receptors in dog cerebral arteries[2].Kynuramine (20 μg/mL) frequently causes a small contraction of the ileum but failed to alter the twitch response to cholinergic stimulation[2].
Kynuramine may serve a physiological role in the modulation of female sexual behavior[3]. Kynuramine increases heart rate and blood pressure in pithed rats[4].
[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4.
[2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6.
[3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51.
[4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6.
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