L-Glutamic Acid (ammonium salt) (Synonyms: Glutamic Acid) |
| カタログ番号GC47563 |
興奮性神経伝達物質
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Cas No.: 7558-63-6
Sample solution is provided at 25 µL, 10mM.
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L-Glutamic acid is a non-essential amino acid and the primary excitatory neurotransmitter in the CNS.1 It acts on ionotropic and metabotropic receptors to induce excitatory synaptic transmission and has roles in synaptic plasticity. Excessive release of L-glutamic acid induces excitotoxicity that is associated with various human diseases, including amyotrophic lateral sclerosis (ALS), stroke, Parkinson's disease, Alzheimer's disease, and Huntington's disease.2 Excessive L-glutamic acid release, in its protonated glutamate form, also occurs during seizure activity and contributes to epileptogenesis and seizure-induced brain damage.3
1.Garattini, S.Glutamic acid, twenty years laterJ. Nutr.130(4S Suppl)901S-909S(2000) 2.Greenamyre, J.T.The role of glutamate in neurotransmission and in neurologic diseaseArch. Neurol.43(10)1058-1063(1986) 3.Barker-Haliski, M., and White, H.S.Glutamatergic mechanisms associated with seizures and epilepsyCold Spring Harb. Perspect. Med.5(8)a022863(2015)
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