LH1307 |
| カタログ番号GC45966 |
PD-1/PD-L1相互作用阻害剤
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2375720-38-8
Sample solution is provided at 25 µL, 10mM.
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LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 3 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 79 and 763 nM, respectively, in reporter assays).
|1. Basu, S., Yang, J., Xu, B., et al. Design, synthesis, evaluation, and structural studies of C2-symmetric small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 protein-protein interaction. J. Med. Chem. 62(15), 7250-7263 (2019).
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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