m-PEG5-Ms |
| カタログ番号GC67171 |
m-PEG5-Ms は、PROTAC の合成に使用できる PEG ベースの PROTAC リンカーです。 m-PEG5-Ms は、抗体薬物複合体 (ADC) の合成に使用される切断可能な ADC リンカーです。
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Cas No.: 130955-38-3
Sample solution is provided at 25 µL, 10mM.
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m-PEG5-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG5-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Sanxing Sun, et al. Triazolotriazine derivatives as a2a receptor antagonists. WO2020002969A1.
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