MC-Val-Ala-PBD (Synonyms: SGD-1910 ) |
| カタログ番号GC39403 |
MC-Val-Ala-PBD は、切断可能なリンカー MC-Val-Ala を介してリンクされた、抗腫瘍抗生物質であるピロロベンゾジアゼピン (PBD、細胞傷害性 DNA 架橋) を使用した ADC の薬物-リンカー コンジュゲートです。
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Cas No.: 1342820-51-2
Sample solution is provided at 25 µL, 10mM.
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MC-Val-Ala-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1].
[1]. Jeffrey SC, et al. A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology. Bioconjug Chem. 2013 Jul 17;24(7):1256-63.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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