Mechlorethamine HCl |
| カタログ番号GC17619 |
メクロレタミン HCl は、粘膜を破壊する発泡剤および壊死性刺激剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 55-86-7
Sample solution is provided at 25 µL, 10mM.
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Chlormethine hydrochloride is a vesicant and necrotizing irritant destructive to mucous membranes. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. Target: Chlormethine is a nitrogen mustard . It is the prototype of alkylating agents, a group of anticancer chemotherapeutic drugs. It works by binding to DNA, crosslinking two strands and preventing cell duplication. It binds to the N7 nitrogen on the DNA base guanine.
References:
[1]. Cao Z, et al. Effect of brentuximab vedotin combined with chlormethine hydrochloride on the treatment of 6 patients with relapsed and refractory Hodgkin lymphoma. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):575-577.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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