Mesterolone (Synonyms: 1α-Methyl-5α-androstan-17β-ol-3-one, 1α-methyl-5α-Dihydrotestosterone, NSC 75054)

Mesterolone is an analytical reference standard categorized as an anabolic androgenic steroid. Formulations containing mesterolone have been used in patients with low testosterone or symptoms of aging male syndrome.^1,2 Mesterolone cannot be aromatized to estrogens, unlike other androgens.^1,3 This compound is the active ingredient in different pharmaceutical preparations that have been used medically but have also been widely applied in sports in order to improve athlete performance.⁴ Mesterolone is regulated as a Schedule III drug in the United States. This product is intended for research and forensic applications.

1.Carruthers, M., Cathcart, P., and Feneley, M.R.Evolution of testosterone treatment over 25 years: Symptom responses, endocrine profiles and cardiovascular changesAging Male18(4)217-227(2015) 2.Dugeroglu, H., Ozturk, M., Atmaca, M., et al.Mesterolone treatment of aging male syndrome improves lower urinary tract symptomsJ. Pak. Med. Assoc.64(12)1366-1369(2014) 3.Lowe, G.D.O., Thomson, J.E., Reavey, M.M., et al.Mesterolone: Thrombosis during treatment, and a study of its prothrombotic effectsBr. J. Clin. Pharmacol.7(1)107-109(1979) 4.Do?owy, M., Pyka-Paj?k, A., Filip, K., et al.A validated TLC-densitometric method for the determination of mesterolone in bulk material and in tabletsBiomed Res. Int.230104(2015)