ML-390 |
| カタログ番号GC19494 |
ML-390はジヒドロオロタートデヒドロゲナーゼ（DHODH）の阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2029049-79-2
Sample solution is provided at 25 µL, 10mM.
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ML-390 is an inhibitor of dihydroorotate dehydrogenase (DHODH), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis.[1] In acute myeloid leukemia, leukemic myeloblast development is halted at an immature stage leading to perpetual self-renewal rather than differentiation. ML-390 induces differentiation in the acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) cell lines with an EC50 value of approximately 2 µM.
Reference:
[1]. Sykes, D.B., Kfoury, Y.S., Mercier, F.E., et al. Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia Cell. 167(1), 171-186 (2016).
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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