Mobocertinib (Synonyms: AP32788, TAK-788) |
| カタログ番号GC47697 |
モボセルチニブ (TAK-788) は、経口活性で不可逆的な EGFR/HER2 阻害剤です。 Mobocertinib は、活性化 EGFRex20ins 変異を含む発癌性バリアントを、野生型 EGFR よりも選択的に強力に阻害します。 Mobocertinib は、NSCLC 研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1847461-43-1
Sample solution is provided at 25 µL, 10mM.
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Mobocertinib is an inhibitor of mutant EGFR and HER2 receptors.1,2 It is selective for the HER2 exon 20 mutants HER2V659E, HER2G660D, HER2G309E, and HER2S310F over wild-type EGFR in Ba/F3 cells.1
1.Chouitar, J., Vincent, S., Brake, R., et al.TAK-788 is a novel and potent tyrosine kinase inhibitor with selective activity against EGFR/HER2AbstractsS811P2(13-32)(2018) 2.Neal, J., Doebele, R., Riely, G., et al.Safety, PK, and preliminary antitumor activity of the oral EGFR/HER2 exon 20 inhibitor TAK-788 in NSCLCAbstractsS599P1(13-44)(2018)
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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