Montbretin A (Synonyms: MbA) |
| カタログ番号GC52032 |
抗糖尿病活性を持つアシル化フラボノールグリコシド
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Cas No.: 115712-92-0
Sample solution is provided at 25 µL, 10mM.
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Montbretin A is an acylated flavonol glycoside that has been found in C. crocosmiiflora and has antidiabetic activity.1,2,3 It inhibits human pancreatic α-amylase and B. fibrisolvens amylase B (Kis = 8.1 and 1,600 nM, respectively).2 Montbretin A reduces blood glucose levels in Zucker diabetic fatty rats when administered at a dose of 7.4 mg/kg per day.4
1.Asada, Y., Hirayama, Y., and Furuya, T.Acylated flavonols from Crocosmia crocosmiifloraPhytochemistry27(5)1497-1501(1988) 2.Williams, L.K., Zhang, X., Caner, S., et al.The amylase inhibitor montbretin A reveals a new glycosidase inhibition motifNat. Chem. Biol.11(9)691-696(2015) 3.Irmisch, S., Jo, S., Roach, C.R., et al.Discovery of UDP-glycosyltransferases and BAHD-acyltransferases involved in the biosynthesis of the antidiabetic plant metabolite montbretin APlant Cell30(8)1864-1886(2018) 4.Yuen, V.G., Coleman, J., Withers, S.G., et al.Glucose lowering effect of montbretin A in Zucker diabetic fatty ratsMol. Cell Biochem.411(1-2)373-381(2016)
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