Mps1-IN-1 dihydrochloride |
| カタログ番号GC50110 |
Mps1-IN-1 二塩酸塩は、強力で ATP 競合性の Mps1 キナーゼ阻害剤であり、IC50 は 367 nM です。 Mps1-IN-1 二塩酸塩は、Mps1 有糸分裂キナーゼ活性を阻害し、スピンドル アセンブリ チェックポイント (SAC) 機能を無効にします。 Mps1-IN-1 二塩酸塩は、がん細胞と「正常な」細胞の両方の生存率を低下させます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883548-93-3
Sample solution is provided at 25 µL, 10mM.
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Selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.
Kwiatkowski et al (2010) Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol. 6 359 PMID:20383151 |Miduturu et al (2011) High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem.Biol. 18 868 PMID:21802008 |Lan and Cleveland (2010) A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell Biol. 190 21 PMID:20624898
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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