MreB Perturbing Compound A22 (Synonyms: A22 hydrochloride) |
| カタログ番号GC44248 |
MreB摂動化合物A22は、MreBのATP結合部位と迅速かつ可逆的に相互作用するベンジルイソチオ尿素化合物です。
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Cas No.: 22816-60-0
Sample solution is provided at 25 µL, 10mM.
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MreB is an actin-like protein expressed in bacteria. It determines the rod shape of cells and has critical roles in cell division, chromosome segregation, and cell polarity. MreB perturbing compound A22 is a benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly. It blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC = 3.1 µg/ml). It interferes with chromosome segregation in C. crescentus by preventing MreB binding to chromosomes. In V. cholerae, A22 prevents the development of normal cell shape and alters nucleoid morphology.
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