N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone (Synonyms: 3oxoC14:1Δ7cis(L)HSL, N-3-oxo-tetradec-7(Z)-enoyl-L-HSL) |
カタログ番号GC40925 |
クオーラムセンシングは、細菌が細胞密度の増加に応じて遺伝子発現を制御するために使用する規制システムです。
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Cas No.: 482598-46-9
Sample solution is provided at 25 µL, 10mM.
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases. AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family. 3-oxo-C14:1-δ7cis-(L)-HSL is a bacterial quorum sensing compound that possesses antimicrobial activity, the ability to inhibit biofilm formation, and exhibits immune suppressive activity. This compound is structurally related to other 3-oxo-monounsaturated (N-acylated homoserine lactones) AHLs such as 3-oxo-C16:1-δ11cis-(L)-HSL (Catalog No. 10011238).
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