N-acetyl-5-Aminosalicylic Acid (Synonyms: Acetylmesalazine, N-acetyl-ASA, N-acetyl Mesalamine, NSC 54183, Salicytamide) |
| カタログ番号GC40298 |
N-アセチル-5-アミノサリチル酸は、抗炎症剤である5-アミノサリチル酸およびそのプロドラッグ形態であるスルファサラジンの代謝物です。
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Cas No.: 51-59-2
Sample solution is provided at 25 µL, 10mM.
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N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine . It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-acetyltransferases. It reduces IFN-γ binding to colonic epithelial cells by 24% when used at a concentration of 10 mM. N-acetyl-5-Aminosalicylic acid (100 µM) scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay and inhibits base hydroxylation in DNA stimulated by hydroxy radicals. Unlike sulfasalazine, N-acetyl-5-aminosalicylic acid does not inhibit 15-hydroxy prostaglandin dehydrogenase (PGDH). Urinary levels of N-acetyl-5-aminosalicylic acid have been used as a marker of 5-ASA adherence in patients with inflammatory bowel disease.
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