NCGC00029283 |
| カタログ番号GC63653 |
NCGC00029283 は、ウェルナー症候群のヘリカーゼヌクレアーゼ (WRN) ヘリカーゼ阻害剤であり、WRN、BLM、FANCJ ヘリカーゼの IC50 はそれぞれ 2.3 μM、12.5 μM、3.4 μM です。
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Cas No.: 714240-31-0
Sample solution is provided at 25 µL, 10mM.
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NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1].
NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1].
[1]. Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019 Jan 9;14(1):e0210525.
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