Octodrine hydrochloride (2-Amino-6-methylheptane (hydrochloride)) (Synonyms: 2-Amino-6-methylheptane, 1,5-dimethyl Hexylamine, NSC 27116)

2-Amino-6-methylheptane hydrochloride is a local anesthetic and vasoconstrictor, but mainly as a pharmaceutical intermediate of octamylamine.

Local anesthesia is produced by tropical application of solutions of the hydrochloride or free base of 2-Amino-6-methylheptane to rabbit's eyes. Intravenously in dogs anesthetized with pentobarbital sodium, 2-Amino-6-methylheptane hydrochloride exhibits 1/500-1/1000 the pressor activity of epinephrine. 2-Amino-6-methylheptane hydrochloride is found to cause an increase in cardiac rate and amplitude of contraction. Intravenously in dogs, anesthetized with pentobarbital sodium, doses of 0.5 to 1.0 mg per kilogram of body weight of 2-Amino-6-methylheptane hydrochloride has no detectable effect on the small intestine, detrusor of the urinary bladder, urine secretion or respiration. Intraperitoneally in rats, 2-Amino-6-methylheptane hydrochloride is found to be almost entirely devoid of a central nervous system stimulating action in non-toxic doses. No histological evidence of irritation of the tracheo-bronchial tree mucosa is noted in rabbits or rats which inhale 2-Amino-6-methylheptane free base daily for 10 and 30 days respectively[1].

[1]. Fellows EJ, et al. The pharmacology of 2-amino-6-methylheptane. J Pharmacol Exp Ther. 1947 Aug;90(4):351-8.