Ogerin (Synonyms: ZINC67740571) |
| カタログ番号GC34697 |
Ogerin は、選択的 GPR68 ポジティブ エイリアシング モジュレーター (PAM) (pEC50=6.83) であり、A2A に対して中程度の拮抗効果があります (Ki=220 nM)。
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Cas No.: 1309198-71-7
Sample solution is provided at 25 µL, 10mM.
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Ogerin is a selective GPR68 positive allosteric modulator, with a pEC50 of 6.83. Ogerin shows inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptoor and weak antagonist activity (Ki, 736 nM) at 5-HT2B receptor. Ogerin blocks recall in fear conditioning in mice[1]. pEC50: 6.83 (GPR68)[1]Ki: 220 nM (A2A receptoor), 736 nM (5-HT2B receptor)[1]
[1]. Huang XP, et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26;527(7579):477-83.
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