MMP-3 Inhibitor VIII (Synonyms: Matrix Metalloproteinase-3 Inhibitor VIII, Stromelysin-1 Inhibitor VIII) |
| カタログ番号GC40624 |
マトリックスメタロプロテアーゼ（MMP）は、細胞移動を可能にするために細胞外マトリックスタンパク質を分解することで、組織の再構築や修復に重要な役割を果たすプロテアーゼファミリーに属しています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 208663-26-7
Sample solution is provided at 25 µL, 10mM.
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Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. MMP-3 (also known as stromelysin-1) is thought to play a role in the vascular remodeling that occurs during aneurysm formation and may also be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII is a cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity. This compound has also been shown to inhibit mouse macrophage metalloelastase MME/MMP-12 with an IC50 value of 13 nM.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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