POT-4 (Synonyms: AL-78898A) |
| カタログ番号GC63151 |
コンプスタチン誘導体である POT-4 (AL-78898A) は、補体因子 C3 活性化の強力な阻害剤です。
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Cas No.: 934461-40-2
Sample solution is provided at 25 µL, 10mM.
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POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation. POT-4 can be used for age-related macular degeneration research[1][2]
A derivative of compstatin, a potent C3 inhibitor, POT-4 is a cyclic peptide that exhibits binding activity to C3, preventing cleavage to its active fragments C3a and C3b[2].
[1]. S. Kaushal, et al. Complement C3 inhibitor POT-4: Clinical Safety of Intravitreal Administration. ARVO Annual Meeting Abstract, 2009 Apr.
[2]. Robyn Troutbeck, et al. Therapeutic targeting of the complement system in age-related macular degeneration: a review. Clin Exp Ophthalmol. Jan-Feb 2012;40(1):18-26.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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