(Rac)-Indoximod |
| カタログ番号GC61750 |
(Rac)-インドキシモド (1-メチル-DL-トリプトファン) は、インドールアミン 2,3-ジオキシゲナーゼ (IDO) 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 26988-72-7
Sample solution is provided at 25 µL, 10mM.
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(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes[1].
(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion[1]. Cell Viability Assay[1] Cell Line: Human cardiac myofibroblasts (hCMs)
[1]. Jun-Won Lee,et al. Co-treatment with interferon-γ and 1-methyl tryptophan ameliorates cardiac fibrosis through cardiac myofibroblasts apoptosis. Mol Cell Biochem. 2019 Aug;458(1-2):197-205.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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