Randialic acid B |
| カタログ番号GC66363 |
トリテルペノイド化合物であるランジアル酸 B は、ホルミル ペプチド受容体 1 (FPR1) 拮抗薬です。ランジアル酸 B は、ヒト好中球の FPR1 を遮断し、in vivo で乾癬様炎症を軽減します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 14021-14-8
Sample solution is provided at 25 µL, 10mM.
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Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo[1].
Randialic acid B (0.1-3 μM; for 5 min) selectively inhibits reactive oxygen species production, elastase release, and CD11b expression in human neutrophils activated by FPR1. Randialic acid B inhibits the binding of N-formyl peptide to FPR1 in human neutrophils, neutrophil-like THP-1 cells, and hFPR1-transfected HEK293 cells, indicating FPR1 antagonism[1].
Randialic acid B acts competitively for its binding to the FPR1 receptor. The FPR1-downstream signaling such as Ca2+ mobilisation and activation of Akt and MAPKs is also competitively inhibited[1].
Randialic acid B shows significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury[2].
Randialic acid B (10 mg/kg; i.v.; every other day; for 5 days) significantly reduces Imiquimod-induced psoriasis-like symptom, including epidermal hyperplasia, desquamation with scaling, neutrophil skin infiltration, and transepidermal water loss[1].
| Animal Model: | BALB/c white female mice (20 g weight; 7-week-old) treated with Imiquimod[1] |
| Dosage: | 10 mg/kg |
| Administration: | i.v.; every other day; for 5 days |
| Result: | Significantly reduced Imiquimod-induced psoriasis-like symptoms. |
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