NE 10790 (3-PEHPC) (Synonyms: 3-PEHPC) |
| カタログ番号GC30592 |
NE 10790 (3-PEHPC) はファルネシルピロリン酸シンターゼ阻害剤としては弱いが、強力なビスホスホネートリセドロネートのホスホノカルボキシレート類似体であり、弱い吸収阻害剤である。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 152831-36-2
Sample solution is provided at 25 µL, 10mM.
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NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.
NE 10790 inhibits incorporation of [14C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I[1].
[1]. Coxon FP, et al. Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages. J Biol Chem. 2001 Dec 21;276(51):48213-22.
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