Saquinavir-d9 |
| カタログ番号GC45974 |
サキナビルの定量化のための内部標準
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1356355-11-7
Sample solution is provided at 25 µL, 10mM.
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Sauinavir-d9 is intended for use as an internal standard for the quantification of saquinavir by GC- or LC-MS. Saquinavir is an HIV protease inhibitor (Kis = 0.12 and <0.1 nM for HIV-1 and HIV-2 protease, respectively) that exhibits antiviral activity with low cytotoxicity.1,2 When co-administered with ritonavir , the bioavailability of saquinavir (20 mg/kg) has been shown to increase 325-fold in mice through a mechanism that inhibits its metabolism by CYP3A.3
|1. Roberts, N.A., Martin, J.A., Kinchington, D., et al. Rational design of peptide-based HIV proteinase inhibitors. Science 248(4953), 358-361 (1990).|2. Tucker, T.J., Lumma, W.C., Jr., Payne, L.S., et al. A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: Synthesis, enzyme inhibition, and antiviral activity. J. Med. Chem. 35(14), 2525-2533 (1992).|3. Tomaru, A., Takeda-Morishita, M., Banba, H., et al. Analysis of the pharmacokinetic boosting effects of ritonavir on oral bioavailability of drugs in mice. Drug Metab. Pharmacokinet. 28(2), 144-152 (2013).
| Cas No. | 1356355-11-7 | SDF | |
| Canonical SMILES | O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN2C[C@](CCCC3)([H])[C@]3([H])C[C@H]2C(NC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=O)C4=NC(C=CC=C5)=C5C=C4 | ||
| Formula | C38H41D9N6O5 | M.Wt | 679.9 |
| 溶解度 | Chloroform: soluble,Methanol: soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.4708 mL | 7.354 mL | 14.708 mL |
| 5 mM | 0.2942 mL | 1.4708 mL | 2.9416 mL |
| 10 mM | 0.1471 mL | 0.7354 mL | 1.4708 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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