Saviprazole (Synonyms: HOE-731) |
カタログ番号GC81723
One-Click Copy Product Info
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Saviprazole (HOE-731) is a H +,K + -ATPase inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 121617-11-6
Sample solution is provided at 25 µL, 10mM.
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In Vivo, Saviprazole (0.03-1 mg/kg; i.v., i.d.; single dose) causes dose-dependent, state-of-stimulation-dependent inhibition of histamine-stimulated gastric acid secretion in Heidenhain pouch dogs, with an ID50 of 0.16 mg/kg i.v. and 0.31 mg/kg i.d.[2]. Saviprazole (0.1-30 mg/kg; i.d.; single dose) causes dose-dependent inhibition of basal and secretagogue-stimulated gastric acid secretion in pylorus-ligated rats, with ID50 values ranging from 0.9 to 2.5 mg/kg[2]. Saviprazole (0.1-1 mg/kg; i.v.; single dose) causes dose-dependent inhibition of receptor- and postreceptor-stimulated gastric acid secretion in anesthetized stomach-lumen-perfused rats, with 0.5 mg/kg reducing IBMX + Forskolin -stimulated secretion by ~70%[2].
In Vitro, Saviprazole (0.1-30 μM; 20 min pre-stimulation) non-competitively inhibits histamine- and dbcAMP-stimulated [14C] aminopyrine uptake in isolated rabbit gastric glands with IC50 values of 0.8 μM and 1.3 μM, respectively, and this inhibition is reversible with Dithioerythritol [1]. Saviprazole (100 μM; 45 min) inhibits dbcAMP-stimulated oxygen consumption in isolated rabbit gastric glands down to basal levels, and this effect is dependent on an acidic parietal cell compartment, as it is fully prevented by 10 mM Imidazole [1]. Saviprazole potently inhibits gastric H+,K+-ATPase and proton transport in gastric vesicles[2].
References:
[1]. Herling AW, et al. The inhibitory effect of HOE 731 in isolated rabbit gastric glands. Biochem Pharmacol. 1990;40(8):1809-1814.
[2]. Herling AW, et al. Gastric acid inhibitory profile of saviprazole (HOE 731) compared to omeprazole. Pharmacology. 1991;43(6):293-303.
| Cas No. | 121617-11-6 | SDF | |
| 同義語 | HOE-731 | ||
| Formula | C15H10F7N3O2S2 | M.Wt | 461.38 |
| 溶解度 | DMSO: 100 mg/mL (216.74 mM; Need ultrasonic) | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1674 mL | 10.8371 mL | 21.6741 mL |
| 5 mM | 433.5 μL | 2.1674 mL | 4.3348 mL |
| 10 mM | 216.7 μL | 1.0837 mL | 2.1674 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >96.00% Appearance: A solid
- COA (Certificate of Analysis)
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)