SHIP2-IN-1 |
| カタログ番号GC65308 |
SHIP2-IN-1 は強力な SHIP2 阻害剤であり、SHIP2 活性を阻害し、IC50 は 2 μM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2252247-80-4
Sample solution is provided at 25 µL, 10mM.
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SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer's disease[1].
SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells[1].
[1]. Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2018 Sep 5;157:405-422.
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