SHS4121705 |
| カタログ番号GC48077 |
ミトコンドリアの解離剤
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2379550-82-8
Sample solution is provided at 25 µL, 10mM.
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SHS4121705 is an orally bioavailable mitochondrial uncoupler.1 It increases oxygen consumption rate in L6 rat myoblast cells with an EC50 value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH).
1.Salamoun, J.M., Garcia, C.J., Hargett, S.R., et al.6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as efficacious mitochondrial uncouplers in STAM mouse model of nonalcoholic steatohepatitisJ. Med. Chem.63(11)6203-6224(2020)
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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