Siomycin A (Synonyms: NSC 285116) |
| カタログ番号GC44892 |
シオマイシン A はチオペプチド抗生物質であり、フォークヘッド ボックス ファミリーの他のメンバーに影響を与えることなく、フォークヘッド ボックス M1(FOXM1) 選択的阻害剤です。シオマイシン A には抗腫瘍作用があり、アポトーシスを促進します。
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Cas No.: 12656-09-6
Sample solution is provided at 25 µL, 10mM.
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The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Siomycin A is a peptide thiazole antibiotic, first isolated from S. sioyaensis, that interacts with the 23S rRNA of bacteria. It inhibits FoxM1 (IC50 = ~5 μM), preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, siomycin A prevents proliferation and induces apoptosis in certain types of stem cells as well as cancer cells.
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