Tilapertin (AMG747) (Synonyms: AMG747) |
| カタログ番号GC31115 |
ティラペルチン (AMG747) は、グリシントランスポーター 1 型 (GlyT1) の経口阻害剤です。
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Cas No.: 1000690-85-6
Sample solution is provided at 25 µL, 10mM.
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Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).
Tilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats[1].
[1]. Dunayevich E, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017 Apr;182:90-97.
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