TUG-1375 |
| カタログ番号GC34938 |
TUG-1375 は遊離脂肪酸受容体 2 (FFA2/GPR43) のアゴニストであり、pKi は 6.69 です。
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Cas No.: 2247372-59-2
Sample solution is provided at 25 µL, 10mM.
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TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ[1]. pKi: 6.69 (FFA2)[1]
TUG-1375 exhibits pEC50 of 7.11 in the cAMP FFA2 assay, also active on murine FFA2 orthologue (pEC50, 6.44 ± 0.13 in the cAMP assay)[1].
[1]. Hansen AH, et al. Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8;61(21):9534-9550.
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