UDP-GalNAz disodium (Synonyms: UDP-N-azidoacetylgalactosamine disodium) |
カタログ番号GC64868
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UDP-GalNAz二ナトリウム(UDP-GalNAz disodium)(UDP-N-アジドアセチルガラクトサミン二ナトリウム)は、UDP-GalNAcの類似物である。UDP-GalNAcは様々なグリコシル化反応の重要な前駆体であり、数多くのN-アセチルガラクトサミニルトランスフェラーゼのドナー基質であり、GalNAcをヌクレオチド糖から炭水化物またはペプチド受容体へ転換させる。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 653600-61-4
Sample solution is provided at 25 µL, 10mM.
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UDP-GalNAz二ナトリウム(UDP-GalNAz disodium)(UDP-N-アジドアセチルガラクトサミン二ナトリウム)は、UDP-GalNAcの類似物である。UDP-GalNAcは様々なグリコシル化反応の重要な前駆体であり、数多くのN-アセチルガラクトサミニルトランスフェラーゼのドナー基質であり、GalNAcをヌクレオチド糖から炭水化物またはペプチド受容体へ転換させる[1]。UDP-GalNAcポリペプチドN-アセチルガラクトサミニルトランスフェラーゼ(GalNAc-Ts)の基質として、UDP-GalNAcは、GalNAc-TsがUDP-GalNAcからα-GalNAcを標的のタンパク質のセリン（Ser）またはスレオニン（Thr）残基に転移することで、ムチン型O-グリコシル化を触媒することを可能とする。このプロセスは、高密度のリポタンパク質コレステロールのレベルの制御において重大な役割を果たし、脂質代謝を影響する[2]。また、UDP-GalNAcは大腸菌K4莢膜多糖類の合成において前駆体として作用している。UDP-GalNAcを使っての大腸菌K4株の代謝工学により、フルクトースコンドロイチンの生産を増強させることができる[3]。更に、UDP-GalNAcはβ-N-アセチルヘキソサミニダーゼの基質として作用し、赤痢アメーバの嚢胞壁の前駆体を生成し、よって大腸の環境におけるこの種の寄生虫の生物化学的な相互作用の理解に寄与している[4]。更に、UDP-GalNAcは、ヒトの血液型A型のグリコシルトランスフェラーゼの基質として機能し、血液型Aの抗原の生合成を促進する[5]。
References：
[1] Willems A P, Van Engelen B G, Lefeber D J. Genetic defects in the hexosamine and sialic acid biosynthesis pathway[J]. Biochim Biophys Acta, 2016, 1860(8): 1640-54.
[2] Guo L, Zhou L, Wei P, et al. Emerging Roles of UDP-GalNAc Polypeptide N-Acetylgalactosaminyltransferases in Cardiovascular Disease[J]. Aging Dis, 2024, 16(1): 239-49.
[3] Restaino O F, Di Lauro I, Cimini D, et al. Monosaccharide precursors for boosting chondroitin-like capsular polysaccharide production[J]. Appl Microbiol Biotechnol, 2013, 97(4): 1699-709.
[4] Nagode A, Vanbeselaere J, Dutkiewicz Z, et al. Molecular characterisation of Entamoeba histolytica UDP-glucose 4-epimerase, an enzyme able to provide building blocks for cyst wall formation[J]. PLoS Negl Trop Dis, 2023, 17(8): e0011574.
[5] Seto N O, Compston C A, Szpacenko A, et al. Enzymatic synthesis of blood group A and B trisaccharide analogues[J]. Carbohydr Res, 2000, 324(3): 161-9.
| Cas No. | 653600-61-4 | SDF | |
| 同義語 | UDP-N-azidoacetylgalactosamine disodium | ||
| Formula | C17H24N6Na2O17P2 | M.Wt | 692.33 |
| 溶解度 | Storage | Store at -20°C, away from moisture | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.4444 mL | 7.222 mL | 14.444 mL |
| 5 mM | 288.9 μL | 1.4444 mL | 2.8888 mL |
| 10 mM | 144.4 μL | 722.2 μL | 1.4444 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)