>>Analytical Standards>>15(S)-HETE-d8

15(S)-HETE-d8 (Synonyms: 15(S)-Hydroxyeicosatetraenoic Acid-d8)

Catalog No.GC46442 Copy One-Click Copy Product Info

An internal standard for the quantification of 15-HETE

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15(S)-HETE-d8 Chemical Structure

Cas No.: 84807-87-4

Size 가격 재고 수량
25 μg
US$274.00
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50 μg
US$520.00
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100 μg
US$984.00
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Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of 15(S)-HETE-d8

15(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 15(S)-HETE by GC- or LC-MS. 15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes.1 15(S)-HETE is present in µg/ml concentrations in the nasal secretions of allergic rhinitis.2

1.Nadel, J.A., Conrad, D.J., Ueki, I.F., et al.Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocyes, leukocytes, and airway cellsJournal of Clinical Investigation871139-1145(1991) 2.Ramis, I., RosellÓ-Catafau, J., Bulbena, O., et al.15-Hydroxyeicosatetraenoic acid as a major eicosanoid in nasal secretions: Assay by high-performance liquid chromatographic-radioimmunoassay and gas chromatographic-mass spectrometric proceduresJournal of Chromatography496416-422(1989)

Chemical Properties of 15(S)-HETE-d8

Cas No. 84807-87-4 SDF
Synonyms 15(S)-Hydroxyeicosatetraenoic Acid-d8
Canonical SMILES CCCCC[C@]([2H])(O)/C([2H])=C/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\CCCC(O)=O
Formula C20H24D8O3 M.Wt 328.5
Solubility 0.1 M Na2CO3: 2 mg/ml,DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,PBS pH 7.2: 0.8 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 15(S)-HETE-d8

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.0441 mL 15.2207 mL 30.4414 mL
5 mM 608.8 μL 3.0441 mL 6.0883 mL
10 mM 304.4 μL 1.5221 mL 3.0441 mL
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In vivo Formulation Calculator (Clear solution) of 15(S)-HETE-d8

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 31 reference(s) in Google Scholar.)

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