8-Prenylnaringenin (Synonyms: Flavaprenin,8-PN) |
Catalog No.GC17119 |
8-prenylnaringenin은 세포독성이 있는 홉 콘(Humulus lupulus)에서 분리된 프레닐플라보노이드입니다. 8-프레닐나린제닌은 내인성 및 외인성 경로 매개 세포자멸사 유도를 통해 HCT-116 결장암 세포에 대해 항증식 활성을 갖는다. 8-Prenylnaringenin은 또한 쥐에서 Akt 인산화 경로의 활성화를 통해 고정화로 인한 근육 위축의 회복을 촉진합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 53846-50-7
Sample solution is provided at 25 µL, 10mM.
IC50: 57 and 68 nM for ERα and ERβ, respectively
8-Prenylnaringenin is an estrogen receptor inhibitor.
The two estrogen receptors ERα and ERβ belong to the nuclear receptor superfamily and are ligand-regulated transcription factors accounting for mediating the physiological effects of the steroid hormone 17α-estradiol. ER is an established target for the development of synthetic ligands for therapeutic applications.
In vitro: Previous study identified 8-prenylnaringenin as a potent phytoestrogen in hops, which had an activity greater than other known plant estrogens. The estrogenic activity of 8-prenylnaringenin was reflected in its relative binding affinity to estrogen receptors from rat uteri. In addition, the presence of 8-prenylnaringenin in hops might explane the accounts of menstrual disturbances in female hop workers [1].
In vivo: Previous animal data demonstrated that 8-prenylnaringenin treatment could result in AMPK signaling pathway activation, therefore suppressing lipogenesis. The consumption of 8-prenylnaringenin was able to prevent body weight gain and improve plasma lipid profile, with significant improvement of insulin resistance and glucose tolerance. Moreove, it was found that 8-prenylnaringenin-enriched diet could ameliorate diabetic-associated metabolic disturbances via regulating glucose and lipid pathways [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Milligan SR, Kalita JC, Heyerick A, Rong H, De Cooman L, De Keukeleire D. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab. 1999 Jun;84(6):2249-52.
[2] Costa R et al. Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice. J Nutr Biochem. 2017 Apr 6;45:39-47.
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