Abciximab (Synonyms: C7E3) |
| Catalog No.GC65597 |
키메라 마우스/인간 단일클론 항체인 Abciximab(C7E3)은 당단백질(GP) IIb/IIIa 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 143653-53-6
Sample solution is provided at 25 µL, 10mM.
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Abciximab (C7E3), a chimeric mouse/human monoclonal antibody, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors[1].
Abciximab (C7E3) inhibits platelet aggregation induced by physiologic and pathologic agonists by binding to the platelet αIIbβ3 integrin[2].Abciximab appears to have similar affinity for the αIIbβ3 and αvβ3 integrins and redistributes between them[2].
Abciximab (C7E3) (0.25 mg/kg/day; i.v.; 28 days) effectively prevents neointimal hyperplasia[2].
[1]. Ibbotson T, et al. Abciximab: an updated review of its therapeutic use in patients with ischaemic heart disease undergoing percutaneous coronary revascularisation. Drugs. 2003;63(11):1121-63.
[2]. Wu CH, et al. Mechanisms involved in the inhibition of neointimal hyperplasia by abciximab in a rat model of balloon angioplasty. Thromb Res. 2001 Feb 1;101(3):127-38.
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