AEG 40730 dihydrochloride |
Catalog No.GC50146
One-Click Copy Product Info
|
IAP antagonist; induces apoptosis
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883545-50-3
Sample solution is provided at 25 µL, 10mM.
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IAP antagonist; binds to the BIR3 domain of cIAP1, cIAP2 and XIAP with nanomolar affinity. Reduces cIAP1, cIAP2 and XIAP protein levels in human breast cancer MDA-MB-231 cells. Induces apoptosis in combination with TNF, and potentiates TRAIL-mediated apoptosis in human colorectal carcinoma HCT 116 cells. Cell permeable.
Beug et al (2014) Smac mimetics and innate immune stimuli synergize to promote tumor death. Nat.Biotechnol. 32 182 PMID:24463573 |Galbán et al (2009) Cytoprotective effects of IAPs revealed by a small molecule antagonist. Biochem.J. 417 765 PMID:18851715 |Bertrand et al (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 30 689 PMID:18570872
| Cas No. | 1883545-50-3 | SDF | |
| Canonical SMILES | O=C([C@H](C)NC)N[C@@H]([C@H](OCC#CC#CCO[C@H](C)[C@H](NC([C@H](C)NC)=O)C(N2[C@H](CN(CCC3=CC=CC=C3)C(C(F)(F)F)=O)CCC2)=O)C)C(N1[C@H](CN(C(C(F)(F)F)=O)CCC4=CC=CC=C4)CCC1)=O.Cl.Cl | ||
| Formula | C52H68F6N8O8.2HCl | M.Wt | 1120.06 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 892.8 μL | 4.464 mL | 8.9281 mL |
| 5 mM | 178.6 μL | 892.8 μL | 1.7856 mL |
| 10 mM | 89.3 μL | 446.4 μL | 892.8 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)