AMG 511 |
| Catalog No.GC39695 |
AMG 511은 PI3Kα, β, δ 및 γ에 대해 각각 4 nM, 6 nM, 2 nM 및 1 nM의 Kis를 갖는 클래스 I PI3K의 강력하고 경구로 이용 가능한 팬 억제제입니다. AMG 511은 p-Akt(Ser473) 감소로 표시되는 PI3K 신호전달을 유의하게 억제합니다. AMG 511은 마우스 교모세포종 이종이식 모델에서 항종양 활성을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1253573-53-3
Sample solution is provided at 25 µL, 10mM.
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AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks, with Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease. AMG 511 exhibits anti-tumor activity in mouse glioblastoma xenograft model[1].
[1]. Mark H Norman, et al. Selective Class I Phosphoinositide 3-kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511. J Med Chem. 2012 Sep 13;55(17):7796-816.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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