AMG 511 |
| Katalog-Nr.GC39695 |
AMG 511 ist ein potenter und oral verfÜgbarer Pan-Inhibitor von PI3Ks der Klasse I mit Kis von 4 nM, 6 nM, 2 nM und 1 nM fÜr PI3Kα, β, δ bzw. γ. AMG 511 unterdrÜckt signifikant die PI3K-Signalisierung, die durch eine Abnahme von p-Akt (Ser473) angezeigt wird. AMG 511 zeigt Anti-Tumor-AktivitÄt im Maus-Glioblastom-Xenograft-Modell.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1253573-53-3
Sample solution is provided at 25 µL, 10mM.
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AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks, with Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease. AMG 511 exhibits anti-tumor activity in mouse glioblastoma xenograft model[1].
[1]. Mark H Norman, et al. Selective Class I Phosphoinositide 3-kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511. J Med Chem. 2012 Sep 13;55(17):7796-816.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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