Amphotericin B methyl ester (Synonyms: LNS-AmB methyl ester) |
| Catalog No.GC60047 |
암포테리신 B 메틸 에스테르는 폴리엔 항생제 암포테리신 B(A634250)의 메틸 에스테르 유도체입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 36148-89-7
Sample solution is provided at 25 µL, 10mM.
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Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester disrupts HIV-1 particle production and potently inhibits HIV-1 replication[1][2].
Amphotericin B methyl ester inhibits HIV-1 particle production with no significant effect on Gag binding to the plasma membrane, Gag association with lipid rafts, or Gag multimerization[1].
[1]. Waheed AA, et al. Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence. J Virol. 2008 Oct;82(19):9776-81. [2]. Keim GR, et al. Comparative toxicological studies of amphotericin B methyl ester and amphotericin B in mice, rats, and dogs. ntimicrob Agents Chemother. 1976 Oct;10(4):687-90.
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