AP1867-2-(carboxymethoxy) (Synonyms: PROTAC FKBP12-binding moiety 2) |
| Catalog No.GC61745 |
AP1867-2-(카르복시메톡시), AP1867(합성 FKBP12F36V 지향 리간드) 기반 부분은 링커를 통해 CRBN 리간드에 결합하여 dTAG 분자를 형성합니다.
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Cas No.: 2230613-03-1
Sample solution is provided at 25 µL, 10mM.
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AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules[1].
dTAG molecules engage FKBP12F36V and CRBN[1].
[1]. Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.
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