Arjunolic Acid |
Catalog No.GC46005 |
아르주놀산은 심플로코스 란시폴리아(Symplocos lancifolia)에서 분리된 사포닌으로 항산화, 항균, 항균, 항염 등 다양한 생물학적 활성을 가지고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 465-00-9
Sample solution is provided at 25 µL, 10mM.
Arjunolic acid is a triterpene that has been found in T. arjuna and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.1,2,3 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay when used at a concentration of 0.8 mM.1 Arjunolic acid (20 mg/kg for four days) prevents arsenic-induced decreases in the activity of superoxide dismutase (SOD1), catalase, GST, and glutathione reductase in mouse brain. It reduces tumor growth in an Ehrlich murine spontaneous adenocarcinoma model when administered at doses of 100 and 250 mg/kg for 20 days.2 Arjunolic acid reduces renal fibrosis and increases in kidney TNF-α and IL-1β levels induced by cisplatin in mice when administered at doses of 100 and 250 mg/kg per day for 10 days.3
|1. Sinha, M., Manna, P., and Sil, P.C. Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain. J. Biochem. Mol. Toxicol. 22(1), 15-26 (2008).|2. Elsherbiny, N.M., and Al-Gayyar, M.M. Anti-tumor activity of arjunolic acid against Ehrlich Ascites Carcinoma cells in vivo and in vitro through blocking TGF-β type 1 receptor. Biomed. Pharmacother. 82, 28-34 (2016).|3. Elsherbiny, N.M., Eladl, M.A., and Al-Gayyar, M.M. Renal protective effects of arjunolic acid in a cisplatin-induced nephrotoxicity model. Cytokine 77, 26-34 (2016).
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