ATR inhibitor 2 |
| Catalog No.GC39645 |
ATR 억제제 2(VX-803)는 150pM 미만의 Ki를 갖는 ATP-경쟁적, 경구 활성 및 선택적 ATR 억제제입니다. ATR 억제제 2는 8nM의 IC50으로 ATR 구동 인산화 체크포인트 키나제-1(Chk1) 인산화를 강력하게 억제합니다. 항종양 활성.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1613191-99-3
Sample solution is provided at 25 µL, 10mM.
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ATR inhibitor 2 is an ATP-competitive, orally active, selective ATR inhibitor, with a Ki of <150 pM. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity[1][2].
[1]. Frank T. Zenke, et al. Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy. Experimental and Molecular Therapeutics. [2]. Gorecki L, et al. Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy. Pharmacol Ther. 2020 Feb 26:107518.
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