AZ1495 |
| Catalog No.GC33054 |
약한 염기인 AZ1495는 강력한 경구 활성 인터루킨-1 수용체 연관 키나제 4(IRAK4) 억제제입니다. AZ1495는 각각 0.005μM 및 0.023μM의 IC50 값으로 IRAK4 및 IRAK1에 대해 유리한 물리화학적 및 키나제 선택성을 갖는다. AZ1495는 0.0007μM의 Kd 값으로 IRAK4 억제를 나타냅니다. AZ1495는 미만성 거대 B 세포 림프종(DLBCL) 연구에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2196204-23-4
Sample solution is provided at 25 µL, 10mM.
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AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL)[1].
[1]. Scott JS, et al. Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. J Med Chem. 2017 Dec 28;60(24):10071-10091.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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