Azetidine-2-carboxylic acid |
| Catalog No.GC33415 |
아제티딘-2-카복실산은 프롤린의 비단백질성 아미노산 동족체입니다. 일반적인 사탕무에서 발견됩니다. 아제티딘-2-카르복실산은 인간을 포함한 많은 종에서 프롤린 대신 단백질에 잘못 통합될 수 있습니다. 독성 및 기형 유발제.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2517/4/6
Sample solution is provided at 25 µL, 10mM.
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Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent[1][2].
Azetidine-2-carboxylic acid (375-5oo μg per day) is incorporated into the collagen synthesized by chick embryo cartilage in vitro[3].
[1]. Rubenstein E, et al. Azetidine-2-carboxylic acid in the food chain. Phytochemistry. 2009 Jan;70(1):100-4. [2]. Rubenstein E, et al. Misincorporation of the proline analog azetidine-2-carboxylic acid in the pathogenesis of multiple sclerosis: a hypothesis. J Neuropathol Exp Neurol. 2008 Nov;67(11):1035-40. [3]. Lane JM, et al. Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. I. Arrest of collagen accumulation in growing chick embryos. Biochim Biophys Acta. 1971 Jun 29;236(3):517-27.
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