BAY-8002 |
| Catalog No.GC19488 |
BAY-8002는 MCT1-발현 DLD-1 세포에서 IC50이 85nM인 모노카르복실레이트 수송체 1(MCT1)의 강력하고 선택적인 경구 활성 억제제이며 MCT4에 대해 탁월한 선택성을 나타냅니다. 항종양 활성.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 724440-27-1
Sample solution is provided at 25 µL, 10mM.
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BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity[1].
BAY-8002 is an inhibitor of MCT1, with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4 (IC50 >50 µM in EVSA-T cells)[1].
Reference:
[1]. Quanz M, et al. Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance. Mol Cancer Ther. 2018 Nov;17(11):2285-2296.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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