BAY-8002 |
| カタログ番号GC19488 |
BAY-8002 は、モノカルボン酸トランスポーター 1 (MCT1) の強力で選択的な経口活性阻害剤であり、MCT1 発現 DLD-1 細胞で 85 nM の IC50 を持ち、MCT4 に対して優れた選択性を示します。抗腫瘍活性。
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Cas No.: 724440-27-1
Sample solution is provided at 25 µL, 10mM.
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BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity[1].
BAY-8002 is an inhibitor of MCT1, with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4 (IC50 >50 µM in EVSA-T cells)[1].
Reference:
[1]. Quanz M, et al. Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance. Mol Cancer Ther. 2018 Nov;17(11):2285-2296.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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