BAZ1A-IN-1 |
| Catalog No.GC63694 |
BAZ1A-IN-1은 BAZ1A(브로모도메인 함유 단백질)의 강력한 억제제입니다. BAZ1A-IN-1은 BAZ1A 브로모도메인에 대해 0.52μM의 KD 값을 보여줍니다. BAZ1A-IN-1은 높은 수준의 BAZ1A를 발현하는 암 세포주에 대해 우수한 항생 활성을 나타내지만, BAZ1A의 낮은 발현 수준을 갖는 암세포에 대해서는 약하거나 전혀 활성을 나타내지 않는다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 941521-45-5
Sample solution is provided at 25 µL, 10mM.
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BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1].
BAZ1A-IN-1 (Cpd-2) (0.015-100 μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1].
[1]. Yang Z, et al. Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation. Bioorg Med Chem Lett. 2021;33:127745.
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