BPK-29 |
| Catalog No.GC34502 |
BPK-29는 C274를 공유적으로 변형하여 비정형적인 고아 핵 수용체 NR0B1-단백질(예: RBM45 및 SNW1) 상호작용을 방해하는 특정 리간드입니다. BPK-29는 KEAP1 돌연변이 암 세포의 고정 독립적 성장을 손상시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2143467-62-1
Sample solution is provided at 25 µL, 10mM.
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BPK-29 is a covalent small molecule that disrupts NR0B1 complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells[1].
BPK-29 substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers[1].
[1]. Woodruff TM,et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008 Dec 15;181(12):8727-34.
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